They asked detailed questions about physical activity, occupation, genealogy of breast cancers, menopausal status, and body mass index. This reduction in risk was obvious if the physical activity occurred early in existence, in the postmenopausal years, or recently. Women who exercise are heavily, in general, older at the right time of the 1st period, and generally have irregular periods and a shortened estrogen-producing phase, which translates in a lower body exposure to estrogen, the researchers say. Similarly, postmenopausal ladies who are physically active have also been shown to have lower degrees of estrogen.The trial got a partial 2-by-2 factorial style. Patients were randomly designated to undergo radiotherapy with or without synchronous chemotherapy with fluorouracil and mitomycin C and either whole-bladder radiotherapy or altered-volume radiotherapy to uninvolved bladder. Recruitment to the dual randomization was motivated but optional, since recruitment in this human population is challenging. Independent randomization was conducted by telephone to the Clinical Trials and Statistics Unit in the Institute of Tumor Research.