* Be faithful. Follow your program every day. Don’t stop and start each period your skin changes. Remember, sometimes your skin layer may appear to worsen early in this program before starting to see improvement. * Follow directions. Not really using the procedure as directed is the most common cause the treatment fails. * Avoid medication prescribed for someone else. This holds true for all medications, especially Accutane.In TOBY and the CoolCap trial, however, not the NICHD trial, sufferers were selected based on the presence of abnormalities on amplitude-integrated electroencephalography furthermore to clinical criteria. Distinctions in local methods for withdrawal of treatment may also have affected outcomes. Withdrawal was somewhat more common in the control group than in the cooled group in the NICHD study but was more prevalent in the cooled group than in the control group in TOBY; these results may partially account for the greater apparent effect of hypothermia on mortality price in the NICHD study as compared with TOBY.