The FDA website warns: All individuals treated with isotretinoin should be observed carefully for symptoms of unhappiness or suicidal thoughts, such as for example sad mood, irritability, acting on harmful impulses, anger, loss of pleasure. Feeling disturbance, psychosis, or aggression. Moreover, statistics show that between 1989 and 2003, there were 216 reported drug-linked suicides among U.S. Teenagers younger than 18. Of these, 72 suicides were linked to Accutane . Another highest amount of suicides for the reason that time period – – 55 – – included Prozac .Because of the novelty of the pandemic H1N1 stress, we prospectively collected data associated with the occurrence of select adverse occasions of special curiosity. These events included many neurologic .13 All laboratory assays were performed by Focus Diagnostics. Primary and Secondary End Points The three coprimary immunogenicity end points after vaccination were chosen according to international guidelines used to judge influenza vaccines.14,15 The coprimary immunogenicity end points were the proportion of subjects with antibody titers of 1 1:40 or even more on hemagglutination-inhibition assay, the proportion of subjects with either seroconversion or a significant upsurge in antibody titer, and the factor upsurge in the geometric mean titer. The secondary safety end points were the frequency, duration, and intensity of adverse events after vaccination and the incidence of serious adverse events and adverse events of special interest through the study period.