Under 500 community pharmacists Just, with wide-ranging experience and post-registration education, took part in the study, carried out by the Division of Medicine and Therapeutics at the University of Aberdeen, UK. ‘The community pharmacists who taken care of immediately the questionnaire were aware of , and concerned by – the presssing issues surrounding off-label prescribing to children, says co-author Dr James McLay. ‘What do concern us was that just 40 percent of pharmacists said they had dispensed off-label medications to kids in the month before the survey. ‘Having reviewed primary care prescribing levels, this 40 percent figure was lower than expected and qualified prospects us to summarize that many pharmacists might not realise that they are dispensing off-label.All P confidence and ideals intervals presented in this report are two-sided. The principal and secondary end points were assessed in the intention-to-treat population and tested through two-sided log-rank tests. Analysis of general and disease-free survival was performed in subgroups which were defined regarding to stratification factors by using univariate Cox analysis. In addition, we performed post hoc subgroup analyses on the basis of histological factors that were known to impact survival.18,19 These factors included the standard of tumor differentiation , the presence or absence of lymphovascular embolization or perineural invasion , resection-margin position, and depth of invasion of the principal tumor. A Cox proportional-hazards model was used to perform multivariate analysis of various factors affecting disease-free of charge and overall survival, including the study intervention.