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The 1st 967 patients who underwent randomization also underwent an interferon-gamma launch assay for tuberculosis . Other checks are detailed in Section 2 in the Supplementary Appendix. All trial lab tests were performed in a single reference laboratory. Tuberculin skin tests weren’t performed. The latter regimen was abandoned in December 2008 due to increased side effects in the upper digestive system.23 IPT contains 300 mg of isoniazid daily, which was started 1 month after enrollment and stopped 7 months following enrollment.‘ACE-536 has the potential to create a significant influence on the treatment of anemia in MDS,’ stated Matthew Sherman, M.D., Chief Medical Officer of Acceleron. ‘Unlike erythropoietin, ACE-536 may target the precise defect in the erythropoietic maturation procedure in MDS individuals and we are optimistic that it could become an important new therapeutic option because of this underserved patient population.’.

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