The study involved 667 patients beneath the supervision of lead investigator, Herbert Lepor, M.D., Professor and Chairman, Division of Urology, at NYU College of Medicine, New York. Patients entered a 1 – to 4-week screening period to confirm severity and balance of voiding symptoms based on the International Prostate Indicator Score . Sufferers were randomly assigned to cetrorelix or placebo in a double-blind fashion in that case. Patients had been administered cetrorelix by intra-muscular injection at Week 0, 2, 26 and 28 . Individuals in treatment Arm C received placebo injections at Week 0, 2, 26 and 28.Critical adverse reasons and events for discontinuing therapy are summarized in Tables S2 and S3, respectively, in the Supplementary Appendix. Primary Outcome Total ratings on the MMAS improved considerably in both groups at six months and at 12 months and 2 years, as compared with baseline scores , but improvements in these ratings were significantly better among women assigned to levonorgestrel-IUS than among those assigned to usual treatment . All six domains of the MMAS favored the levonorgestrel-IUS at each and every time point .